Do SNPs Underlie Drug Abuse and Cardiac Disease Comorbidity?
SNPs - Cancer Incidences & Pharmacogenomics
Miller Drug Abuse And Social Issues– Clinical Aspe Cts Paper Only
Cochin Pharmacology And The Future: Drug Abuse And Contraception
Effects Of Drug Abuse In Secondary Schools
Techniques Used In Managing Drug Abuse In Secondary Schools In Kenya
Factors Contributing to Drug Abuse Among the Youths in Kenya
The Relationship between Drug Abuse and Domestic Violence in Kenya
SOCIALIZATION AND DRUG ABUSE AMONG STUDENTS
Neuroproteomics of Drug Abuse and Traumatic Brain Injury Biomarkers
Functional Genetics and Psychiatric Disorders
Knowledge on Health Effects of Drug Abuse
What is Drug and Substance Abuse
Drug Abuse Among Secondary School Students
Social Capital and Drug Abuse Treatment among Puerto Rican Women
Brain injury can exist in different forms; such conditions occur after mechanical trauma, such as traumatic brain injury (TBI) or after exposure to a number of recreational drugs such as MDMA, methamphetamine, or cocaine. Recent findings have provided some preliminary data showing that brain injury and drug abuse insults may share common pathway(s)leading to neuronal cell injury. Such pathways may be mediated by the activation of the protease families: the pronecrotic calpain and the proapoptotic caspase systems. These proteases can act on a number of substrates including the cytoskeletal proteins resulting in the breakdown products of such proteins can be used as biomarkers for brain injury insult (mechanical and chemical). The field of proteomics has been introduced as a new discipline for biomarker identification that allows for deciphering protein expression at very low concentrations. Having this in mind, neuroproteomics approach has been applied to identify the differential alterations of protein markers involved in two models of experimental traumatic brain injury as well as in drug abuse which showed high similarity in the underlying mechanisms leading to neuronal injury.