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    Regulation of Vascular Smooth Muscle Phenotype by Notch Signaling joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Regulation of Vascular Smooth Muscle Phenotype by Notch Signaling купить
    Regulation of Vascular Smooth Muscle Phenotype by Notch Signaling
    6341 Руб
      High Glucose Regulation of Human Vascular Thrombin Receptor PAR-4 joshua boucher regulation of vascular smooth muscle phenotype by notch signaling High Glucose Regulation of Human Vascular Thrombin Receptor PAR-4 купить
      High Glucose Regulation of Human Vascular Thrombin Receptor PAR-4
      5852 Руб
        Vascular Morphogenesis is regulated by Wnt signaling via PDZRN3 joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Vascular Morphogenesis is regulated by Wnt signaling via PDZRN3 купить
        Vascular Morphogenesis is regulated by Wnt signaling via PDZRN3
        7628 Руб
          Notch signaling and stromal microenvironment in acute leukemia joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Notch signaling and stromal microenvironment in acute leukemia купить
          Notch signaling and stromal microenvironment in acute leukemia
          4788 Руб
            Regulation of fluid-shear stress by mechanosensory primary cilia joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Regulation of fluid-shear stress by mechanosensory primary cilia купить
            Regulation of fluid-shear stress by mechanosensory primary cilia
            5765 Руб
              Function and Regulation of Drosophila Epsin joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Function and Regulation of Drosophila Epsin купить
              Function and Regulation of Drosophila Epsin
              5765 Руб
                Regulation of gene Expression joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Regulation of gene Expression купить
                Regulation of gene Expression
                4788 Руб
                  NOTCH signaling as a novel target for cancer joshua boucher regulation of vascular smooth muscle phenotype by notch signaling NOTCH signaling as a novel target for cancer купить
                  NOTCH signaling as a novel target for cancer
                  5765 Руб
                    CMAM-MUSCLE03 Anatomical Vascular Never Model of Upper Limb Muscle , Medical Science Educational Teaching Anatomical Models joshua boucher regulation of vascular smooth muscle phenotype by notch signaling CMAM-MUSCLE03 Anatomical Vascular Never Model of Upper Limb Muscle , Medical Science Educational Teaching Anatomical Models купить
                    CMAM-MUSCLE03 Anatomical Vascular Never Model of Upper Limb Muscle , Medical Science Educational Teaching Anatomical Models
                    18033.19 Руб
                      Regulation of B cell Development by Antigen Receptors joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Regulation of B cell Development by Antigen Receptors купить
                      Regulation of B cell Development by Antigen Receptors
                      4788 Руб
                        Characterization of a Terminal Flower Mutant Phenotype of B. palonga joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Characterization of a Terminal Flower Mutant Phenotype of B. palonga купить
                        Characterization of a Terminal Flower Mutant Phenotype of B. palonga
                        4875 Руб
                          Phenotype Preservation of Chondrocytes for Cartilage Repair joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Phenotype Preservation of Chondrocytes for Cartilage Repair купить
                          Phenotype Preservation of Chondrocytes for Cartilage Repair
                          6644 Руб
                            Capillary flow during graded handgrip muscle work by means of CEUS joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Capillary flow during graded handgrip muscle work by means of CEUS купить
                            Capillary flow during graded handgrip muscle work by means of CEUS
                            4875 Руб
                              Cerebral Subcortical infarcts with Leukoencephalopathy joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Cerebral Subcortical infarcts with Leukoencephalopathy купить
                              Cerebral Subcortical infarcts with Leukoencephalopathy
                              2397 Руб
                                Rapid Signaling Of Estrogen To Neuronal Dendrite Spine Formation joshua boucher regulation of vascular smooth muscle phenotype by notch signaling Rapid Signaling Of Estrogen To Neuronal Dendrite Spine Formation купить
                                Rapid Signaling Of Estrogen To Neuronal Dendrite Spine Formation
                                4788 Руб
                                Diabetes is associated with enhanced thrombin generation, atherothrombosis and vascular remodelling. Clotting factor thrombin could modify these pathologies via protease-activated receptors- PAR-1, PAR-3 and PAR-4, exerting pleiotropic effects on vascular cells. This study investigates the possible regulation of thrombin receptors by high glucose in vascular smooth muscle cells (SMC). Treatment of human saphenous vein SMCs with high glucose selectively increased PAR-4 but not PAR-1 and PAR-3 expression, which was mediated via PKC and NF?B. High glucose mediated-ROS generation via NAD(P)H oxidase or other pro-oxidants such as Ang-II or exogenous H2O2 also enhanced PAR-4 expression. PAR-4 upregulation was associated with enhanced SMC migration, calcium signaling and inflammatory gene expression in responses to thrombin or PAR-4AP. The positive staining for PAR-4 and its colocalization with SMC was seen in the vicinity of the intimal plaque region of diabetic atherosclerotic plaques. This study highlights a unique role of PAR-4 in hyperglycemic settings, which might contribute to the enhanced cellular effects of thrombin and exaggerated cardiovascular complications of diabetes.

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